DEAR DR. BLONZ: I enjoy seafood of all types, but I am concerned that some are high in cholesterol. How concerned should I be about the high cholesterol levels in some kinds of seafood? : Animal-derived foods do contain cholesterol; most seafood contains about the same amount as skinless poultry and other sources of lean meat. We now know that shellfish have more cholesterol than other fish, but they are not as rich in cholesterol as was once thought. The connection between dietary cholesterol, blood cholesterol and heart disease is not always clear.