Dear Reader: We have only to look to language to see how closely grief and bereavement are associated with physical pain. Heartsore, heartsick, heartache, brokenhearted -- each word draws a direct line between the emotion of grief and its profound effect on the human body. Research shows that, in addition to being an emotional challenge, grief and grieving can indeed take a physical toll on the human body. Research into the physical effects of grief suggests that the immune system gets involved by mounting an inflammatory response. The psychological pain of grief can put your physical health in jeopardy.