DEAR DR. BLONZ: I am hoping to learn more about hyaluronic acid as a dietary supplement for wrinkles. I know it is used medically -- injected into joints to help those with arthritis -- but until recently, I hadn’t heard anything about it being taken orally. : While not a medical doctor or aesthetician, I can provide some background on hyaluronic acid and those claims associated with its use as a dietary supplement. When a substance is injected, what happens does not automatically translate to a similar effect when taken as a dietary supplement. There is no convincing evidence or reason to believe that hyaluronic acid, taken orally, will have a significant anti-wrinkle ability.