To get some advice on how to manage an aggressive cat, Mental Floss spoke with Shawna Garner, DVM, Lead Veterinarian for the pet assistance app FirstVet. \"When faced with an aggressive cat, the offending person should leave the room immediately and allow the cat to calm down with the owner,\" Garner says. Give the Cat a Time-OutAn aggressive cat is best left to its own devices whenever possible. Don’t Block a Cat’s Escape RouteIf you’re in a confrontation with a cat, don’t idle in front of a doorway while deciding whether or not to leave. Treat Cat Wounds SeriouslyIf a cat manages to bite or scratch you, take it seriously.